The Cord Factor: Structure, Biosynthesis and Application in Drug Research – Achilles Heel of Mycobacterium tuberculosis?
نویسندگان
چکیده
Recently, it was reported that the tuberculosis mortality in 2009 has dropped to 35% since 1990 (WHO, 2010). Nevertheless, the disease caused by the facultative intracellular bacterial pathogen Mycobacterium tuberculosis still remains the leading cause of death from a single bacterial species (Coker, 2004; Russell et al., 2010). The emergence of Multi-Drug Resistant (MDR) and Extreme Drug Resistant (XDR) strains of M. tuberculosis leads to prolonged treatment which drastically increases the therapy costs.
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